The South American spirits category includes cachaça, pisco, aguardiente and other spirits indigenous to South America.

Pisco is a grape based spirit originating in the grape growing regions of Peru, and Chile. Essentially pisco is a pomace brandy and is distilled from the leftover pomace, or solid remains, leftover after grapes are pressed during the winemaking process. The term "pisco" is recognized as an appellation throughout the world and is reserved for these grape based spirits of Peru and Chile.

Cachaça is a sugar cane based spirit originating in Brazil. Similar to Pisco, the term cachaça is recognized as an appellation reserved for these Brazilian spirits. Although similar in style to rum, these spirits are not to be confused. Cachaça is distilled only from fresh sugar cane juice, like agricole rhum, not molasses like most rums on the market,; it is commonly produced as either unaged or wood-aged.