Cristalino mezcal is a spirit from Mexico that can be made from as many as 18 different types of the agave plant, some cultivated and some wild. Most are produced in the Mexican state of Oaxaca. A cristalino mezcal is an aged mezcal that has been filtered to remove color and may contain additional flavors. It is distilled in a copper still (sometimes double distilled) aged in oak, then filtered, thus preserving a clear appearance.

Mezcal is often confused with tequila, as both are made from agave. But while tequila must be made from one specific blue agave, mezcal can be produced from eighteen different types of agave (maguey). There are two types of mezcal, those made exclusively from maguey and those made from at least 80% maguey mixed with other ingredients. Mezcal has similar aging terms as tequila, such as reposado and añejo, but generally mezcal is more of an artisanal product, so examples of mezcal vary more than tequila.

Most are double-distilled, while some are triple-distilled and then aged for several years in oak barrels. Flavors range from smoked herbs and pepper to tobacco and charred fruits. Serve these on their own, in an adventuresome cocktail, or with a cigar.