While there are several important red wine regions in Spain, such as Rioja, Priorat and Ribera del Duero, other regions are home to some distinctive wines. The largest of these is Castilla-La Mancha, neat the cities of Toledo and Madrid in central Spain. This is one of the largest expanses of vineyards in the world; red wines range from lighter-styled reds to Gran Riservas made from Tempranillo, much in the style of the best wines of Rioja. Wines from La Mancha are relative values.

Other regions include Catalonia in northeastern Spain where Penedès and Empordà wines originate as well as Alicante from the province of Valencia on Spain's south east coast.