Barbera from Piedmont is the best-known example of this wine type. The most widely planted red variety in the region, there are numerous styles produced today, from rustic and light to more powerful and age-worthy.

There are several recognized designations for Piedmont Barbera, most notably Barbera d'Alba and Barbera d'Asti. Named for the cities and surrounding zones where vineyards are situated, Barbera d'Alba tends to be more traditional in style (high acid) while Barbera d'Asti is often characterized by a riper style with less acidity; these wines often receive more small oak aging.

While there are still many examples of the rustic style of Barbera (earthy notes), the fruit-driven, ripe style of Barbera has beome popular as of late; this has also meant an increase in prices.